Thermobiology and Host Swapping in Malaria
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چکیده
Mechanisms of temperature adaptation in eukaryotes have been extensively studied during constant temperature acclimation, but relatively little is known about how organisms cope with life in fluctuating thermal environments. For free-living organisms, fluctuations may occur over time scales of hours to days or seasonally. Parasites can experience a change in their thermal habitat when they move between hosts during different life history stages. The malarial parasite, Plasmodium falciparum, is one such case. The first life stage occurs in the human host, which has a high body temperature, ranging from 37°C to 41°C during fever. The second two stages occur in the cooler mosquito host, which lives in habitats that commonly range from 20 to 30°C. In their Nature Brief Communication, Fang and McCutchan describe an investigation of the regulation of the transcription of a ribosomal RNA molecule in P. falciparum at different temperatures, which they hope will help us to understand how the parasite senses and reacts to it’s changing environment.
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